The effect of concentration and chemical form on the gastrointestinal absorption of neptunium

John Harrison*, D. S. Popplewell, A. J. David

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

The gastrointestinal absorption of neptunium at low mass concentrations as 239Np nitrate (0·5-1 ng Np; 2-5 μg l-1) has been found to be 0·03, 0·02 and 0·18 per cent in adult rats, hamsters and rabbits, respectively. Administration as 239Np bicarbonate increased uptake in the rat to 0·15 per cent but had no significant effect on uptake in either the hamster or the rabbit. Absorption in the rat was also increased to 0·14 per cent for 239Np citrate but not for either 239Np phytate (0·04 per cent) or 239Np incorporated into rat liver (0·01 per cent). The fasting of rats for 8 hours increased their subsequent absorption of 239Np as the bicarbonate to 0·25 per cent. The absorption of neptunium at high mass concentrations as 237Np nitrate (0·5 mg Np, 5 g l-1) was increased to 0·26 per cent in the rat compared with the value of 0·03 per cent for 239Np (0·5 ng, 5 μg l-1) but a similar effect of concentration was not observed in the hamster. The results support the use of a value of absorption of 0·1 per cent instead of 1 per cent in calculations of annual limits on intake of radioisotopes of neptunium by workers and in estimates of radiation doses resulting from the ingestion of contaminated food and water by adult members of the public.

Original languageEnglish
Pages (from-to)269-277
Number of pages9
JournalInternational Journal of Radiation Biology
Volume46
Issue number3
DOIs
Publication statusPublished - 1984

Bibliographical note

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

  • Gastrointestinal absorption
  • Neptunium

Fingerprint

Dive into the research topics of 'The effect of concentration and chemical form on the gastrointestinal absorption of neptunium'. Together they form a unique fingerprint.

Cite this