The efficacies of pure LICAM(C) and DTPA for enhancing the elimination of plutonium-238 and americium-241 from rats after their inhalation as nitrate

G. N. Stradling*, J. W. Stather, S. A. Gray, J. C. Moody, Michele Ellender, Alan Hodgson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

After the inhalation of 238Pu and 241Am as nitrate, the repeated administration of DTPA is far superior to that of LICAM(C) for enhancing their elimination from the body. The therapeutic efficacies of these chelating agents are however similar after intravenous injection of 238Pu as citrate. It is concluded that DTPA should remain the agent of choice for treating persons contaminated internally with transportable forms of these actinides.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalExperimental Pathology
Volume37
Issue number1-4
DOIs
Publication statusPublished - 1989

Bibliographical note

Funding Information:
This work was partly funded by the Commission of the European Communities under research contracts BI6-D-089-UK. LICAM(C) was synthesised by Dr. BURGADA and colleagues at the Pierre and Marie Curie University, Paris. We thank Ms. K. WOOD for animal care.

Keywords

  • DTPA, inhalation
  • LICAM(C), inhalation
  • americium
  • diethylenetriaminepenta-acetic acid (DTPA)
  • inhalation DTPA
  • inhalation LICAM(C)
  • plutonium

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