The efficacies of pure LICAM(c) and DTPA on the retention of plutonium-238 and americium-241 in rats after their inhalation as nitrate and intravenous injection as citrate

G. N. Stradling*, J. W. Stather, S. A. Gray, J. C. Moody, Michele Ellender, Alan Hodgson, V. Volf, D. M. Taylor, P. Wirth, P. W. Gaskin

*Corresponding author for this work

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25 Citations (Scopus)

Abstract

The pure carboxylated catechoyl amide LICAM(C) and the calcium and zinc salts of diethylenetriaminepenta-acetic acid (DTPA), were tested for efficacy for removing 238Pu and 241Am from rats after inhalation of the nitrate or intravenous injection of the citrate. The results were compared with the efficacy of methylated LICAM(C) used in previous experiments. It was shown that: (1) after inhalation of 238Pu nitrate, DTPA was far superior to pure LICAM(C); (2) after intravenous injection of 238Pu citrate, the infusion of DTPA plus LICAM(C) was only marginally more effective than DTPA alone; and (3) after inhalation or intravenous injection of 238Pu plus 241Am, the efficacy of pure LICAM(C) was only marginally more effective than the methylated form and neither form was effective for the decorporation of 241Am. It was concluded that DTPA, at present, remains the chelating agent of choice for treating persons accidentally contaminated with transportable forms of Pu and Am.

Original languageEnglish
Pages (from-to)503-514
Number of pages12
JournalInternational Journal of Radiation Biology
Volume56
Issue number4
DOIs
Publication statusPublished - 1989

Bibliographical note

Funding Information:
Acknowledgements This work was partly funded by the Commission of the European Communities under research contracts B16-D-089-UK and B16-D-091-D . The pure form of LICAM(C) was synthesized by Dr Burgada and co-workers at the Pierre and Marie Curie University, Paris . We thank Ms K . Wood and Mrs B . Eggmann for animal care .

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