The gastrointestinal absorption of organically bound forms of plutonium in fed and fasted hamsters

John Harrison*, J. R. Cooper, J. A. Bomford, A. J. David

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)

    Abstract

    Values of about 0·005-0·01 per cent were obtained for the absorption in fed hamsters of plutonium ingested as Pu4+ citrate, isocitrate, phytate and malate complexes and Pu3+ ascorbate compared with about 0·003-0·004 per cent for Pu4+ nitrate. Replacing drinking water with tea did not affect the result for Pu4+ nitrate. Fasting hamsters for 8 h before the administration of plutonium citrate increased absorption to 0·1-0·2 per cent. An extra period of fasting for 4 h after administration did not lead to a further increase in absorption. Similar values were also obtained when plutonium citrate was administered after a 24 h fast, followed either by immediate access to food or a further 4 h fast. In hamsters fasted for 24 h before administration of either Pu3+ ascorbate or Pu4+ nitrate, about 6-7 per cent of the ingested plutonium was retained in the gastrointestinal tract after one week. At three weeks after ingestion of Pu3+ ascorbate, gastrointestinal retention had fallen 100-fold without an increase in absorption.

    Original languageEnglish
    Pages (from-to)1083-1091
    Number of pages9
    JournalInternational Journal of Radiation Biology
    Volume50
    Issue number6
    DOIs
    Publication statusPublished - 1986

    Keywords

    • Gastrointestinal absorption
    • Plutonium

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