The Impact of "omic" and Imaging Technologies on Assessing the Host Immune Response to Biodefence Agents

Julia Tree, Helen Flick-Smith, Michael J. Elmore, Caroline A. Rowland

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

Understanding the interactions between host and pathogen is important for the development and assessment of medical countermeasures to infectious agents, including potential biodefence pathogens such as Bacillus anthracis, Ebola virus, and Francisella tularensis. This review focuses on technological advances which allow this interaction to be studied in much greater detail. Namely, the use of "omic" technologies (next generation sequencing, DNA, and protein microarrays) for dissecting the underlying host response to infection at the molecular level; optical imaging techniques (flow cytometry and fluorescence microscopy) for assessing cellular responses to infection; and biophotonic imaging for visualising the infectious disease process. All of these technologies hold great promise for important breakthroughs in the rational development of vaccines and therapeutics for biodefence agents.

Original languageEnglish
Article number237043
JournalJournal of Immunology Research
Volume2014
DOIs
Publication statusPublished - 16 Sep 2014

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