The influence of age and gender on the incidence of drug resistance in tuberculosis

J. Herbert, J. M. Watson, Francis Drobniewski, R. Williams, E. G. Smith, J. G. Magee, B. Watt, W. P. Ferguson, M. Chadwick

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The UK Mycobacterial Resistance Network (MYCOBNET) has received reference laboratory reports on around 12,500 initial isolates of M tuberculosis complex for the years 1993 to 1996. Within this dataset, as at 31/7/97, males are more likely than females to exhibit resistance to any first line drug (6.5% versus 5.8%), and to exhibit multi-drug resistance (MDR - resistance to Isoniazid and Rifampicin with or without resistance to other drugs) (1.4% versus 0.8%). In adults, drug resistance drug decreases with increasing age. Possible confounding factors have been examined, initially in univariate analyses, including HIV status, ethnic group, geographical location, country of origin and previous episodes of tuberculosis. A multivariate analysis suggests that while gender exerts minimal independent influence (OR male : female for resistance to any first line drug = 1.18, 95% CIs 1.01 - 1.37), the incidence of drug resistance is associated with younger age (OR 15 - 44 years : 65+ years for resistance to any first line drug = 2.40, 95% CIs 1.89 - 3.04). Other important factors are previous tuberculosis and HIV status.

Original languageEnglish
Pages (from-to)A34
JournalThorax
Volume52
Issue numberSUPPL. 6
Publication statusPublished - Dec 1997

Fingerprint

Dive into the research topics of 'The influence of age and gender on the incidence of drug resistance in tuberculosis'. Together they form a unique fingerprint.

Cite this