The influence of thioacetamide upon plutonium deposition in the rat

Robert Bulman*, R. J. Griffin, A. T. Russell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

It has been shown that the distribution of plutonium in rats can be influenced by oral administration of thioacetamide (300 mg/kg). Rats injected intraperitoneally with plutonium citrate retained 71.5 and 23.6% of the recovered activity in the carcass and liver, respectively, whereas rats which had been treated with thioacetamide 24 hr previously contained 35.8 and 59.5% of the plutonium in the carcass and liver, respectively. It is possible that the hepatic phospholipids, the concentrations of which are increased by thioacetamide, act as ionophores in the concentration of cations in the liver.

Original languageEnglish
Pages (from-to)123-126
Number of pages4
JournalToxicology and Applied Pharmacology
Volume41
Issue number1
DOIs
Publication statusPublished - Jul 1977

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