The Metabolism of Ceramic and Non-ceramic Forms of Uranium Dioxide after Deposition in the Rat Lung

G. N. Stradling, J. W. Stather, S. A. Gray, J. C. Moody, Alan Hodgson, D. Sedgwick, N. Cooke

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Ceramic and non-ceramic forms of uranium dixoide, produced industrially, were administered to rats either by inhalation or as an aqueous suspension which was injected directly into the pulmonary region of the lungs. The results showed that: 1 both materials should be assigned to inhalation class Y as defined by the International Commission on Radiological Protection; 2 whilst the translocation of uranium to the blood for the non-ceramic UO2 was about twice that obtained for the ceramic form, the two dioxides were unlikely to be differentiated on the basis of their lung retention kinetics; 3 the distribution of uranium amongst body tissues and the relationship between systemic content and cumulative urinary excretion indicated that it was transported in the hexavalent form; 4 in addition to air sampling procedures, lung radioactivity counting measurements could be used to advantage for assessing occupational exposures; 5 the exposure limits should be based on radiation dose rather than chemical toxicity.

Original languageEnglish
Pages (from-to)133-139
Number of pages7
JournalHuman & Experimental Toxicology
Volume7
Issue number2
DOIs
Publication statusPublished - Mar 1988

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