The relationship between colony-forming ability and chromosomal aberrations induced in human t-lymphocytes after γirradiation

J. S. Prosser*, Alan Edwards, D. C. Lloyd

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Using aliquots from the same samples of irradiated normal human blood, T-lymphocyte survival was measured by (a) 14-day colony growth, (b) the proportion of chromosomally normal first post-irradiation metaphases and (c) the proportion of cells not suffering interphase death and delay within 48 h after irradiation. Combining (b) and (c) gives a prediction of the proportion of cytogenetically undamaged cells which reach metaphase after 48 h. These cells should be capable of producing viable colonies under suitable culture conditions. A comparison of these values with those observed in (a) shows a reasonable agreement in accordance with the hypothesis that gross chromosomal damage and cell reproductive death are closely related.

Original languageEnglish
Pages (from-to)293-301
Number of pages9
JournalInternational Journal of Radiation Biology
Volume58
Issue number2
DOIs
Publication statusPublished - 1990

Bibliographical note

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

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