Trends in incidence of thick, thin and in situ melanoma in Europe

L. Sacchetto*, R. Zanetti, H. Comber, C. Bouchardy, D. H. Brewster, P. Broganelli, M. D. Chirlaque, D. Coza, J. Galceran, A. Gavin, M. Hackl, A. Katalinic, S. Larønningen, M. W.J. Louwman, E. Morgan, T. E. Robsahm, M. J. Sanchez, L. Tryggvadóttir, R. Tumino, E. Van EyckenSally Ann Vernon, V. Zadnik, S. Rosso

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)

Abstract

Background: We analysed trends in incidence for in situ and invasive melanoma in some European countries during the period 1995–2012, stratifying for lesion thickness. Material and methods: Individual anonymised data from population-based European cancer registries (CRs) were collected and combined in a common database, including information on age, sex, year of diagnosis, histological type, tumour location, behaviour (invasive, in situ) and lesion thickness. Mortality data were retrieved from the publicly available World Health Organization database. Results: Our database covered a population of over 117 million inhabitants and included about 415,000 skin lesions, recorded by 18 European CRs (7 of them with national coverage). During the 1995–2012 period, we observed a statistically significant increase in incidence for both invasive (average annual percent change (AAPC) 4.0% men; 3.0% women) and in situ (AAPC 7.7% men; 6.2% women) cases. Discussion: The increase in invasive lesions seemed mainly driven by thin melanomas (AAPC 10% men; 8.3% women). The incidence of thick melanomas also increased, although more slowly in recent years. Correction for lesions of unknown thickness enhanced the differences between thin and thick cases and flattened the trends. Incidence trends varied considerably across registries, but only Netherlands presented a marked increase above the boundaries of a funnel plot that weighted estimates by their precision. Mortality from invasive melanoma has continued to increase in Norway, Iceland (but only for elder people), the Netherlands and Slovenia.

Original languageEnglish
Pages (from-to)108-118
Number of pages11
JournalEuropean Journal of Cancer
Volume92
DOIs
Publication statusPublished - Mar 2018

Bibliographical note

Funding Information:
Lidia Sacchetto presented this work at the IACR Meeting 2016 in Marrakesh (Morocco) and has been awarded the “Enrico Anglesio” Prize, offered by the Anglesio Moroni Foundation , Turin, Italy. This study was supported by a research grant (grant number 2015.AI329.U390 ) of the Fondazione Cassa di Risparmio di Torino , Turin, Italy; the grant funded a one-year scholarship to LS. The authors would like to thank the TIM WG (Trends in Melanoma Working Group) members for contributing to this study with their data. The N. Ireland Cancer Registry is funded by the Public Health Agency (PHA).

Funding Information:
Lidia Sacchetto presented this work at the IACR Meeting 2016 in Marrakesh (Morocco) and has been awarded the ?Enrico Anglesio? Prize, offered by the Anglesio Moroni Foundation, Turin, Italy. This study was supported by a research grant (grant number 2015.AI329.U390) of the Fondazione Cassa di Risparmio di Torino, Turin, Italy; the grant funded a one-year scholarship to LS. The authors would like to thank the TIM WG (Trends in Melanoma Working Group) members for contributing to this study with their data. The N. Ireland Cancer Registry is funded by the Public Health Agency (PHA).

Publisher Copyright:
© 2018 Elsevier Ltd

Keywords

  • Breslow
  • Melanoma incidence trends
  • Melanoma mortality trends
  • Thickness
  • Thin lesions

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