Trends in survival for teenagers and young adults with cancer in the UK 1992-2006

C. O'Hara, A. Moran, J. S. Whelan, R. E. Hough, Charles Stiller, M. C.G. Stevens, D. P. Stark, R. G. Feltbower, M. G. McCabe*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


Background Although relatively rare, cancer in teenagers and young adults (TYA) is the most common disease-related cause of death and makes a major contribution to years of life lost in this age group. There is a growing awareness of the distinctive needs of this age group and drive for greater understanding of how outcomes can be improved. We present here the latest TYA survival trends data for the United Kingdom (UK). Methods Using national cancer registry data, we calculated five-year relative survival for all 15-24 year olds diagnosed with cancer or a borderline/benign CNS tumour in the UK during the periods 1992-1996, 1997-2001 and 2002-2006. We analysed trends in survival for all cancers combined and for eighteen specified groups that together represent the majority of TYA cancers. We compared our data with published data for Europe, North America and Australia. Results Five-year survival for all cancers combined increased from 75.5% in 1992-1996 to 82.2% in 2002-2006 (P < 0.001). Statistically significant improvements were seen for all disease groups except osteosarcoma, rhabdomyosarcoma, non-gonadal and ovarian germ cell tumours and ovarian and thyroid carcinomas. During the earliest time period, females had significantly better survival than males for five of the twelve non-gender-specific disease groups. By the latest period, only melanomas and non-rhabdomyosarcoma soft tissue sarcomas had differential survival by gender. Survival in the UK for the most recent period was generally similar to other comparable countries. Conclusion Five-year survival has improved considerably in the UK for most cancer types. For some disease groups, there has been little progress, either because survival already approaches 100% (e.g. thyroid carcinomas) or, more worryingly for some cancers with poor outcomes, because they remain resistant to existing therapy (e.g. rhabdomyosarcoma). In addition, for a number of specific cancer types and for cancer as a whole males continue to have worse outcomes than females.

Original languageEnglish
Article number9515
Pages (from-to)2039-2048
Number of pages10
JournalEuropean Journal of Cancer
Issue number14
Publication statusPublished - 23 Jun 2015

Bibliographical note

Funding Information:
This research was supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre (JSW and REH) Public Health England (AM and CAS) and the Teenage Cancer Trust (DPS and MGM).

Publisher Copyright:
© 2015 The Authors.


  • Adolescent
  • Cancer
  • Outcomes
  • Survival
  • TYA
  • Teenage
  • Trends
  • UK


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