Trends in the prevalence and management of pre-stroke atrial fibrillation, the South London Stroke Register, 1995-2014

Vageesh Jain, Iain J. Marshall, Siobhan L. Crichton, Christopher McKevitt, Anthony G. Rudd, Charles D.A. Wolfe

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4 Citations (Scopus)

Abstract

Background Previous studies have found low use of anticoagulation prior to stroke, in people with atrial fibrillation (AF). This study examined data on patients with AF-related stroke from a population-based stroke register, and sought to examine changes in management of AF prior to stroke, and reasons for suboptimal treatment, in those who were known to be at a high risk of stroke. Methods The South London Stroke Register (SLSR) is an ongoing population-based register recording first-in-a-lifetime stroke. Trends in the prevalence of AF, and antithrombotic medication prescribed before the stroke, were investigated from 1995 to 2014. Multivariable logistic regression analyses were conducted to assess the factors associated with appropriate management. Results Of the 5041 patients on the register, 816 (16.2%) were diagnosed with AF before their stroke. AF related stroke increased substantially among Black Carribean and Black African patients, comprising 5% of the overall cohort in 1995-1998, increasing to 25% by 2011-2014 (p<0.001). Anticoagulant prescription in AF patients at high-risk of stroke (CHADS2 score [> = 2]) increased from 9% (1995-1998) to 30% (2011-2014) (p<0.001). Antiplatelet prescription was more commonly prescribed throughout all time periods (43% to 64% of high-risk patients.) Elderly patients (>65) were significantly less likely to be prescribed an anticoagulant, with ethnicity, gender and deprivation showing no association with anticoagulation. Conclusions Most AF-related strokes occurred in people who could have been predicted to be at high risk before their stroke, yet were not prescribed optimal preventative treatment. The elderly, despite being at highest stroke risk, were rarely prescribed anticoagulants.

Original languageEnglish
Article numbere0175980
JournalPLoS ONE
Volume12
Issue number4
DOIs
Publication statusPublished - Apr 2017
Externally publishedYes

Bibliographical note

Funding Information:
CW and CM acknowledge support from the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London.

Funding Information:
CW and CM acknowledge support from the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care South London at King's College Hospital NHS Foundation Trust.

Funding Information:
IJM acknowledges support from the UK Medical Research Council (MRC), through its Skills Development Fellowship program, grant MR/N015185/1

Publisher Copyright:
© 2017 Jain et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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