Twenty years of bacterial genome sequencing

Nicholas J. Loman, Mark J. Pallen*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

140 Citations (Scopus)

Abstract

Twenty years ago, the publication of the first bacterial genome sequence, from Haemophilus influenzae, shook the world of bacteriology. In this Timeline, we review the first two decades of bacterial genome sequencing, which have been marked by three revolutions: whole-genome shotgun sequencing, high-throughput sequencing and single-molecule long-read sequencing. We summarize the social history of sequencing and its impact on our understanding of the biology, diversity and evolution of bacteria, while also highlighting spin-offs and translational impact in the clinic. We look forward to a 'sequencing singularity', where sequencing becomes the method of choice for as-yet unthinkable applications in bacteriology and beyond.

Original languageEnglish
Pages (from-to)787-794
Number of pages8
JournalNature Reviews Microbiology
Volume13
Issue number12
DOIs
Publication statusPublished - 1 Dec 2015
Externally publishedYes

Bibliographical note

Funding Information:
N.J.L. and M.J.P. are supported by the Medical Research Council (MRC)-funded Cloud Infrastructure for Microbial Bioinformatics (CLIMB) project (reference number MR/L015080/1).

Publisher Copyright:
© 2015 Macmillan Publishers Limited.

Fingerprint

Dive into the research topics of 'Twenty years of bacterial genome sequencing'. Together they form a unique fingerprint.

Cite this