UK epidemic Escherichia coli strains A-E, with CTX-M-15 β-lactamase, all belong to the international O25:H4-ST131 clone

Siu Ha Lau, Mary E. Kaufmann, David Livermore, Neil Woodford, Geraldine A. Willshaw, Thomas Cheasty, Katie Stamper, Suganya Reddy, John Cheesbrough, Frederick J. Bolton, Andrew Fox, Mathew Upton

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136 Citations (Scopus)

Abstract

Objectives: Uropathogenic and invasive Escherichia coli O25:H4-ST131 isolates producing CTX-M-15 extended-spectrum β-lactamase (ESBL) enzymes have recently been shown to be disseminated across the globe. In the UK, many CTX-M-15 ESBL-producing E. coli strains have been previously defined as belonging to the epidemic strains A-E, as determined by PFGE. The present study was carried out to define the relationship between these two groups of pathogenic E. coli. Methods: Multilocus sequence typing and PFGE were used for molecular characterization of a collection of 61 ESBL-producing E. coli isolates from across the UK. Results: Strains A to E all belonged to the ST131 clone, further underscoring the epidemiological importance of this lineage. Conclusions: The future spread of the ST131 clone, and its UK variants, should be monitored closely and the pathogenic mechanisms explaining their success should be investigated.

Original languageEnglish
Pages (from-to)1241-1244
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Volume62
Issue number6
DOIs
Publication statusPublished - 2008

Keywords

  • Extended-spectrum β-lactamases
  • MLST
  • Molecular epidemiology
  • Multilocus sequence typing
  • PFGE
  • UPEC
  • Uropathogenic Escherichia coli

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