UK vaccination schedule: Persistence of immunity to hepatitis B in children vaccinated after perinatal exposure

Tom A. Yates, Karthikeyan Paranthaman, Ly Mee Yu, Elizabeth Davis, Sarah Lang, Scott J. Hackett, Steven B. Welch, Andrew J. Pollard, Matthew D. Snape

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Objective: To assess persistence of immunity to hepatitis B (HBV) in primary school children vaccinated following perinatal exposure. Design: Serological survey. Setting: Five UK sites (Berkshire East, Birmingham, Buckinghamshire, Milton Keynes and Oxfordshire). Participants: Children from 3 years 4 months to 10 years of age (mean age 6.2 years), vaccinated against HBV from birth following perinatal exposure. Interventions: A single booster dose of the paediatric formulation of a recombinant HBV vaccine. Main outcome measures: Titres of antibody against hepatitis B Surface Antigen (anti-HBs) measured immediately before and 21-35 days after the HBV vaccine booster. Results: Prebooster anti-HBs titres were >10 mIU/ml in 84.6% of children (n=26; 95% CI 65.1 to 95.6%). All children (n=25, 95% CI 86.3 to 100%) had titres >100 mIU/ml after the booster. Conclusions: This study of antibody persistence among UK children born to hepatitis B infected women, immunised with a 3-dose infant schedule with a toddler booster suggests sustained immunity through early childhood. These data should prompt further studies to address the need for a preschool booster. Trial registration: Eudract Number 2008-004785-98.

Original languageEnglish
Pages (from-to)429-433
Number of pages5
JournalArchives of Disease in Childhood
Volume98
Issue number6
DOIs
Publication statusPublished - Jun 2013

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