Uniting to end the TB epidemic: Advances in disease control from prevention to better diagnosis and treatment

Ibrahim Abubakar*, Marc Lipman, Timothy D. McHugh, Helen Fletcher

*Corresponding author for this work

Research output: Contribution to journalEditorial

8 Citations (Scopus)

Abstract

Tuberculosis is a major global cause of morbidity and mortality. Despite recent advances in containing the epidemic, several challenges continue to slow progress towards elimination including the continuing impact of drug resistant disease, and the lack of appropriate tools. Curtailing the transmission of tuberculosis remains a challenge especially in high burden countries. New developments in measuring correlates of protection are urgently needed to support the evaluation of vaccines. Similarly, despite progress in molecular diagnostics, better tools are required to identify resistance to antibiotics in multi and extensively drug resistant tuberculosis. Whole Genome Sequencing may lead to the next generation of assays to rapidly detect resistance and evaluate transmission. Advances on shortening treatment are hampered by the lack of a biomarker of cure which obviates the current long wait for relapses in trials. New research is urgently needed to support development of new vaccines and better diagnostics tools and shorter treatment for drug sensitive and resistant tuberculosis.

Original languageEnglish
Article number47
JournalBMC Medicine
Volume14
Issue number1
DOIs
Publication statusPublished - 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
� 2016 Abubakar et al.

Keywords

  • Elimination
  • Multi-drug resistant tuberculosis
  • Tuberculosis

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