The uptake of the uranyl cation (UO2 2+) into the liver of the normal rat does not exceed 0.25% of the amount injected. However, the uptake can be enhanced to 7.5% by thioacetamide intoxication, a condition characterized by the presence of acidic phospholipids in the liver. Alternatively, if 1,2-diheptanoyl-dl-glycerosphorphoric acid is injected simultaneously with UO2 2+, 69.8% of the injected activity is taken up into the liver. As UO2 2+ cannot be extracted into organic solvents by any of the phospholipids present in the cell membranes of mammalian cells, it might be inferred that UO2 2+ does not enter liver cells because of the absence of phospholipid-type ionophores specific for UO2 2+ +.
|Number of pages||4|
|Journal||International Journal of Nuclear Medicine and Biology|
|Publication status||Published - 1980|