Use of DTPA for increasing the rate of elimination of plutonium-238 and americium-241 from rodents after their inhalation as the nitrates

J. W. Stather, G. N. Stradling, S. A. Gray, J. Moody, Alan Hodgson

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

This study has shown that: 1. both inhaled (2 μmol/kg) and injected (30 μmol/kg) diethylenetriaminepentaacetic acid (DTPA) can reduce the lung deposit of 238Pu and 241Am inhaled as nitrate to about 1% of that in untreated controls; 2. injection of DTPA is more effective than aerosolized DTPA for reducing deposits of 238Pu and 241Am in the liver and skeleton; 3. combined treatment involving early inhalation of DTPA followed by repeated intravenous injections is likely to be the most effective treatment for workers who have accidentally inhaled plutonium and americium nitrates.

Original languageEnglish
Pages (from-to)573-582
Number of pages10
JournalHuman Toxicology
Volume4
Issue number6
DOIs
Publication statusPublished - 1985

Fingerprint

Dive into the research topics of 'Use of DTPA for increasing the rate of elimination of plutonium-238 and americium-241 from rodents after their inhalation as the nitrates'. Together they form a unique fingerprint.

Cite this