Use of high frequency jet ventilation as a refinement for imaging macaques with respiratory disease

Sally Sharpe*, Shaun Scott, Irene Taylor, Oliver Skinner, Simon Clark, Donna Smyth, Anthony McIntyre, Fergus V. Gleeson, Michael Dennis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Imaging is used in human medicine to diagnose disease and monitor treatment efficacy. Computed tomography (CT) positron emission tomography (PET) and magnetic resonance (MR) are applied to animal models of infectious diseases to increase data quality, enhance their relevance to the clinical situation, and to address ethical issues through reduction of numbers and refinement of study designs. The time required for collection of MR and PET-CT scans means that normal breathing produces motion artefacts that can render images unacceptable. We report, for the first time, the use of high frequency jet ventilation (HFJV) for respiratory management during imaging of macaques. HFJV enables continuous gaseous exchange, resulting in cessation of spontaneous breathing motion thus providing a motionless field without the potential stresses induced by repeated breath-hold strategies.

Original languageEnglish
Pages (from-to)386-390
Number of pages5
JournalLaboratory Animals
Volume54
Issue number4
DOIs
Publication statusPublished - 1 Aug 2020

Keywords

  • jet ventilation
  • non-human primate
  • PET-CT imaging
  • respiratory management

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