Varicella zoster immune status in children treated for acute leukemia

Soonie R. Patel*, Jessica Bate, Peter A.C. Maple, Kevin Brown, Judith Breuer, Paul T. Heath

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Children treated for acute leukemia are at increased risk of severe infection with varicella zoster virus (VZV). We studied the VZV sero-status of children with acute leukemia prior to starting chemotherapy and after completion of chemotherapy. VZV sero-status was assessed using time resolved fluorescence immunoassay (TRFIA) before starting treatment and 6 months after completion of treatment. Prior to starting treatment for acute leukemia, a significant proportion of children (35%) are VZV seronegative. On completion of treatment most patients maintained protective VZV antibody levels; however, 35% had reduced/loss VZV antibody to a level considered non-protective and susceptible to VZV infection.

Original languageEnglish
Pages (from-to)2077-2079
Number of pages3
JournalPediatric Blood and Cancer
Volume61
Issue number11
DOIs
Publication statusPublished - 1 Nov 2014

Bibliographical note

Publisher Copyright:
© 2014 Wiley Periodicals, Inc.

Keywords

  • Acute leukemia
  • Children
  • Immunity
  • Varicella zoster virus

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