Virus antibody survey in different european populations indicates risk association between coxsackievirus B1 and type 1 diabetes

Sami Oikarinen, Sisko Tauriainen, Didier Hober, Bernadette Lucas, Andriani Vazeou, Amirbabak Sioofy-Khojine, Evangelos Bozas, Peter Muir, Hanna Honkanen, Jorma Ilonen, Mikael Knip, Päivi Keskinen, Marja Terttu Saha, Heini Huhtala, Glyn Stanway, Christos Bartsocas, Johnny Ludvigsson, Keith Taylor, Heikki Hyöty

Research output: Contribution to journalArticlepeer-review

90 Citations (Scopus)

Abstract

Enteroviruses (EVs) have been connected to type 1 diabetes in various studies. The current study evaluates the association between specific EV subtypes and type 1 diabetes by measuring typespecific antibodies against the group B coxsackieviruses (CVBs), which have been linked to diabetes in previous surveys. Altogether, 249 children with newly diagnosed type 1 diabetes and 249 control children matched according to sampling time, sex, age, and country were recruited in Finland, Sweden, England, France, and Greece between 2001 and 2005 (mean age 9 years; 55% male). Antibodies against CVB1 were more frequent among diabetic children than among control children (odds ratio 1.7 [95% CI 1.0-2.9]), whereas other CVB types did not differ between the groups. CVB1-associated risk was not related to HLA genotype, age, or sex. Finnish children had a lower frequency of CVB antibodies than children in other countries. The results support previous studies that suggested an association between CVBs and type 1 diabetes, highlighting the possible role of CVB1 as a diabetogenic virus type.

Original languageEnglish
Pages (from-to)655-662
Number of pages8
JournalDiabetes
Volume63
Issue number2
DOIs
Publication statusPublished - Feb 2014

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