Virus detection and monitoring of viral load in Crimean-Congo hemorrhagic fever virus patients

Roman Wölfel, Janusz T. Paweska, Nadine Petersen, Antoinette A. Grobbelaar, Patricia A. Leman, Roger Hewson, Marie Claude Georges-Courbot, Anna Papa, Stephan Günther, Christian Drosten

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    87 Citations (Scopus)

    Abstract

    We developed a real-time reverse transcription - PCR that detected 1,164 copies/mL of Crimean-Congo hemorrhagic fever virus per milliliter of serum at 95% probability (probit analysis) and was 100% concordant with nested PCR on 63 samples from 31 patients with confirmed infection. Infected patients who died appeared to have higher viral loads; low viral loads correlated with IgG detection.

    Original languageEnglish
    Pages (from-to)1097-1100
    Number of pages4
    JournalEmerging Infectious Diseases
    Volume13
    Issue number7
    DOIs
    Publication statusPublished - Jul 2007

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