Waterborne Elizabethkingia meningoseptica in adult critical care

Luke S.P. Moore*, Daniel S. Owens, Annette Jepson, Jane Turton, Simon Ashworth, Hugo Donaldson, Alison H. Holmes

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Elizabethkingia meningoseptica is an infrequent colonizer of the respiratory tract; its pathogenicity is uncertain. In the context of a 22-month outbreak of E. meningoseptica acquisition affecting 30 patients in a London, UK, critical care unit (3% attack rate) we derived a measure of attributable morbidity and determined whether E. meningoseptica is an emerging nosocomial pathogen. We found monomicrobial E. meningoseptica acquisition (n = 13) to have an attributable morbidity rate of 54% (systemic inflammatory response syndrome ≥2, rising C-reactive protein, new radiographic changes), suggesting that E. meningoseptica is a pathogen. Epidemiologic and molecular evidence showed acquisition was water-source–associated in critical care but identified numerous other E. meningoseptica strains, indicating more widespread distribution than previously considered. Analysis of changes in gram-negative speciation rates across a wider London hospital network suggests this outbreak, and possibly other recently reported outbreaks, might reflect improved diagnostics and that E. meningoseptica thus is a pseudo-emerging pathogen.

Original languageEnglish
Pages (from-to)9-17
Number of pages9
JournalEmerging Infectious Diseases
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 2016

Bibliographical note

Publisher Copyright:
© 2016, Centers for Disease Control and Prevention (CDC). All rights reseved.

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

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