Web based scoring is useful for validation and harmonisation of scoring criteria within RENEB

Horst Romm*, Elizabeth Ainsbury, Joan Francesc Barquinero, Leonardo Barrios, Christina Beinke, Alexandra Cucu, Mercedes Moreno Domene, Silvia Filippi, Octávia Monteiro Gil, Eric Gregoire, Valeria Hadjidekova, Vasia Hatzi, Carita Lindholm, Radhia M´kacher, Alegria Montoro, Jayne Moquet, Mihaela Noditi, Ursula Oestreicher, Fabrizio Palitti, Gabriel PanteliasMaría Jesús Prieto, Irina Popescu, Kai Rothkamm, Natividad Sebastià, Sylwester Sommer, Georgia Terzoudi, Antonella Testa, Andrzej Wojcik

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Purpose: To establish a training data set of digital images and to investigate the scoring criteria and dose assessment of the dicentric assay within the European network of biodosimetry (RENEB), a web based scoring inter-comparison was undertaken by 17 RENEB partners. Materials and methods: Two sets of 50 high resolution images were uploaded onto the RENEB website. One set included metaphases after a moderate exposure (1.3 Gy) and the other set consisted of metaphases after a high dose exposure (3.5 Gy). The laboratories used their own calibration curves for estimating doses based on observed aberration frequencies. Results: The dose estimations and 95% confidence limits were compared to the actual doses and the corresponding z-values were satisfactory for the majority; only the dose estimations from two laboratories were too low or too high. The coefficients of variation were 17.6% for the moderate and 11.2% for the high dose. Metaphases with controversial results could be identified for training purposes. Conclusions: Overall, the web based scoring of the two galleries by the 17 laboratories produced very good results. Application of web based scoring for the dicentric assay may therefore be a relevant strategy for an operational biodosimetry assistance network.

Original languageEnglish
Pages (from-to)110-117
Number of pages8
JournalInternational Journal of Radiation Biology
Volume93
Issue number1
DOIs
Publication statusPublished - 2 Jan 2017

Bibliographical note

Funding Information:
We are very grateful for the extremely efficient and thoughtful technical and organizational work performed by Martina Denk, Claudia Kerscher and Jennifer Reis. This work was supported by the EU within the 7th Framework Programme [EURATOM grant agreement No. 295513].

Publisher Copyright:
© 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Keywords

  • Web based scoring
  • biodosimetry network
  • biological dosimetry
  • dicentric assay
  • radiation

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