WHO 'Treatment as Prevention' guidelines are unlikely to decrease HIV transmission in the UK unless undiagnosed HIV infections are reduced

Alison Brown, Anthony Nardone, Valerie Delpech

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

The WHO guidelines recommend antiretroviral therapy (ART) begins when CD4R cell counts reach less than 500 cells to reduce HIV transmission. In the UK, 96 000 people were living with HIV (PLWHIV) in 2011, ART coverage was 84% amongthe diagnosed population and 42% of PLWHIV had detectable viraemia. Using published methods, we estimate starting ART at below 500 CD4R cells could have reduced the proportion of PLWHIV with detectable viraemia from 42% to 38%, whereas halving the undiagnosed population could have led to a decrease to 28%. In the UK, it is unlikely early treatment will reduce HIV transmission unless the undiagnosed population is substantially reduced.

Original languageEnglish
Pages (from-to)281-283
Number of pages3
JournalAIDS
Volume28
Issue number2
DOIs
Publication statusPublished - 14 Jan 2014

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